diff --git a/Marlin/src/inc/Conditionals_LCD.h b/Marlin/src/inc/Conditionals_LCD.h
index 654db63f05..7a657efae8 100644
--- a/Marlin/src/inc/Conditionals_LCD.h
+++ b/Marlin/src/inc/Conditionals_LCD.h
@@ -534,3 +534,16 @@
 #define IS_CARTESIAN !IS_KINEMATIC
 
 #define HAS_ACTION_COMMANDS (defined(ACTION_ON_KILL) || defined(ACTION_ON_PAUSE) || defined(ACTION_ON_PAUSED) || defined(ACTION_ON_RESUME) || defined(ACTION_ON_RESUMED) || defined(ACTION_ON_CANCEL) || defined(G29_ACTION_ON_RECOVER) || defined(G29_ACTION_ON_FAILURE) || defined(ACTION_ON_FILAMENT_RUNOUT))
+
+#ifndef INVERT_X_DIR
+  #define INVERT_X_DIR false
+#endif
+#ifndef INVERT_Y_DIR
+  #define INVERT_Y_DIR false
+#endif
+#ifndef INVERT_Z_DIR
+  #define INVERT_Z_DIR false
+#endif
+#ifndef INVERT_E_DIR
+  #define INVERT_E_DIR false
+#endif
diff --git a/Marlin/src/module/stepper.cpp b/Marlin/src/module/stepper.cpp
index 10c524bdc8..72032dcb60 100644
--- a/Marlin/src/module/stepper.cpp
+++ b/Marlin/src/module/stepper.cpp
@@ -129,10 +129,10 @@ Stepper stepper; // Singleton
 
 // private:
 
-block_t* Stepper::current_block = NULL; // A pointer to the block currently being traced
+block_t* Stepper::current_block; // (= NULL) A pointer to the block currently being traced
 
-uint8_t Stepper::last_direction_bits = 0,
-        Stepper::axis_did_move;
+uint8_t Stepper::last_direction_bits, // = 0
+        Stepper::axis_did_move; // = 0
 
 bool Stepper::abort_current_block;
 
@@ -2143,14 +2143,20 @@ void Stepper::init() {
     E_AXIS_INIT(5);
   #endif
 
-  set_directions();
-
   // Init Stepper ISR to 122 Hz for quick starting
   HAL_timer_start(STEP_TIMER_NUM, 122);
 
   ENABLE_STEPPER_DRIVER_INTERRUPT();
 
   sei();
+
+  // Init direction bits for first moves
+  last_direction_bits = 0
+    | (INVERT_X_DIR ? _BV(X_AXIS) : 0)
+    | (INVERT_Y_DIR ? _BV(Y_AXIS) : 0)
+    | (INVERT_Z_DIR ? _BV(Z_AXIS) : 0);
+
+  set_directions();
 }
 
 /**